Ketamine: a new view on therapeutic opportunities in psychiatric practice

Ketamine: a new view on therapeutic opportunities in psychiatric practice

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This article is a review of evidence-based research in English for the past 15 years thanks to access via a database PubMed and Medline, about the new features out of borstlist sj?lvh?ftande claimed indications of the well-known short--acting anesthetic, ketamine.Latter being the antagonist of NMDA receptors by activating glutamatergic transmission has antidepressant effects.One intravenous infusion of 0.5 mg/kg of ketamine for 40 minutes can provide fast antidepressant effect, during the bipolar and monopolar resistant depression, especially with high risk of suicide.

Instability of welspun spaces double bedsheet antidepressant effect of ketamine from a few hours to several weeks is demonstrated.It is also proved the effectiveness of ketamine in obsessive-compulsive and posttraumatic frustration.Intramuscular, oral and intranasal routes of applications are researched.Ketamin can probably serve as a therapeutic alternative in some patients with pharmacotherapy resistant depression except patients with substance abuse or a history of psychosis.